Anjana Ahuja
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The news coming out of the laboratory was scary. Not only had a promising new HIV vaccine failed, it may have increased the incidence of the disease in previously healthy volunteers. Scientists are now working hard to discover the cause of the biggest setback to HIV vaccine research for years.
The mystery, which has attracted almost no attention but could have huge implications for all vaccine research, centres on the V520 vaccine developed by Merck. The vaccine comprised a common cold virus with three HIV genes stitched into it (the cold virus is used simply to smuggle the HIV genes into the body). The plan, as with any vaccine, was that these harmless HIV genes would goad the immune system into making antibodies capable of fighting off a genuine infection.
Fifteen hundred high-risk, healthy individuals - many were sex workers - received the vaccine in 2005. Two years later the vaccinated group were just as likely to have caught HIV as the group who received a placebo, showing the vaccine didn't work.
But closer inspection revealed something seriously amiss among participants who, when recruited, had high levels of antibodies to the cold virus. When these cold-sensitive people were vaccinated their risk of getting HIV doubled compared with cold-sensitive people who received a placebo.
The vaccine itself will not have infected participants but scientists are desperate to find out why it apparently made recipients more vulnerable to infection. “We are analysing the data to try to determine if the results are due to immune responses induced by the vaccine, differences in study populations, or some other biological phenomenon,” said Dr Keith Gottesdiener, of Merck Research Laboratories.
The findings will be crucial, given that cold viruses are regularly used in experimental vaccines. One Merck researcher said that “the whole field will come apart at the seams” without an intensive investigation.
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Leafing through my Penguin Book of Historic Speeches I happened upon an oration given by the suffragette Emmeline Pankhurst. During her era, a child born in wedlock had only one legal parent - the father. She said: “[If women had the vote] .. . the law would have said that as Nature has given to children two parents, so the law should recognise that they have two parents.” We can safely assume she meant one of each gender.
How odd, then, it seems for me to be attending a conference in Westminster tonight on the “need for a father”. The issue of paternity is being examined for its relevance to the welfare of a child born to two lesbians.
Neither nature nor science can yet create a human life from just two biological mothers or two biological fathers. For the State, therefore, to excise men from the business of parenting seems dishonest as well as discriminatory.
Anjana Ahuja joined The Times in 1994, and writes for times2 and the comment pages. In her Science Notebook she writes about science, medicine and technology, and their impact on society. She holds a PhD in space physics from Imperial College, London. She is currently on maternity leave.
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Thank you for the comments. The piece on same-sex parenting is separate from the HIV piece, although maybe that's not as clear online as it is in print. My take on same-sex parenting is this: I fail to see how the state's deletion of the father's role, even if it is just providing sperm, can be a good thing. The more we know about genes, the more we learn of their influence on our lives (one estimate is that approx 80 per cent of personality is down to biology). I fully support the right of children to know their biological origins, even if guardians do not wish it, and as neither science nor nature can create a child from either two women or two men, the state should not collude to deceive the child that he/she has been created this way.
One another note, three HIV genes stitched into a cold virus will not give anyone HIV. But - and this is the story - perhaps their linkage to a cold virus makes a subsection of the population more vulnerable to HIV infection from outside.
anjana ahuja, london,
Accept The Lord Jesus as Saviour ,live your life by His rules and watch Hiv/Aids slowly come under control,or live by societies rules and watch it destroy tens of millions more,
the proof is in the statistics
John Tate England
John tate, Chester le street, Durham
The planet needs this virus, like malaria, to keep the population down a bit. It would help if there were more of these fatal infection.
m wilson, bidache, france
Mating HIV DNA to cold virus DNA.
I see no problem here.
I mean, what could possibly go wrong?
Donald Cameron, Dundas, Canada
Ron,
Your immense ingorance is utterly breathtaking. Ryan White? Ring a bell in that hollow head of yours? Your singular solution to a complex problem sounds eerily similar to that of a brain washed religious nut who is incapable of independent thought. Newsflash, Ron, children are born with HIV in this world. While a vaccine may not cure them, ultimate eradication of the disease, coupled with responsible reproduction and lifestyle practices, wouldn't be a bad thing. I wish you luck on your long, arduous, and perhaps unattainable, road to enlightenment.
Dana, Des Moines, IA
I'm sorry, what does the second half of your article have to do with the first? From HIV to same sex parenting?
And about the above post--woman from Bangor, Maine-- injecting someone with the virus in question is the definition of a vaccine. Antibodies are usually produced in the body as a cause of a weakened version of the virus or bacteria...or in the case of Smallpox, a virus similar to that of the one in question.
Shannon, Washington, D.C.
"Neither nature nor science can yet create a human life from just two biological mothers or two biological fathers."
Um, Anjana -- sorry, perhaps I'm a little dense, but, um -- did you intend the above statement to be the basis for an argument against same-sex parenting? If so, it is not a very sound one.
Humans are no longer "natural" creatures. We haven't been for several million years. That, after all, is the very point of being human, as opposed to an animal? We adapt the "natural order" to suit ourselves.
Whether something is "naturally possible" is a non-argument. Not even your common, every-day produce section banana is "natural" anymore, is it?
Werner Liebenberg, Johannesburg, South Africa
I know a cure 100% effective. keep your legs closed and your pants up.
Simple but effective
Ron Nielsen, Palisade,
the difference is, when making a vaccine like this, the entire HIV is not stitched in the cold virus--all that's changed about the cold virus is its appearance. It's like it's dressed in new clothes. As we learned in elementary school, antibodies are creating through recognizing and latching onto immune system threats. Once antibodies are created for a specific germ, they continue to fight the germ--this is why you don't catch chicken pox twice. So what these scientists do is take the relatively harmless cold germ and make it appear like the HIV germs.
This is similar to how Merck made the Human Pappilomavirus (HPV--causes genital warts, possibly cervical cancer) vaccine Gardasil (released last year), though they use yeast organisms then, rather than cold germs.
Anna, Warren,
Dear Emily,
I find your comment to be rather patronising. The public has every right to question the design of any vaccine. However, yes, ofcourse we must look at the science:
Merck's HIV vaccine flop brings vectors under closer scrutiny
Heidi Ledford
Nat Biotechnol. 2008 Jan;26(1):3-4.
You say: 'There is no possible way that a person who was infected with these genes would get HIV or AIDS. Plus the likelihood of these cloned viruses getting anywhere near members of the public would be so miniscule as to be insignificant.'
Really? Ordinary cold viruses can be spread quite easily (as most people know) and even if the cloned viruses have been engineered in such way as to limit/prevent their spread from one individual to another, viruses have the capacity to mutate either on their own or by genetic exchange;hence, the worldwide concern about about bird flu. Furthermore, you should remember that the volunteers in these studies are themselves 'members of the public'.
Milla, Vienna,
HIV needs an immune cell to attack it for it to enter the cell and complete its lifecycle. So it isn't too surprising that increasing antibody levels increases susceptibility to infection.
Disappointing, of course, but if we knew the answers it wouldn't be research.
Malcolm McLean, Bradford, UK
Mike, learn some science before you start making wild accusations - only three genes from the virus were "stiched" into the cold virus. There is no possible way that a person who was infected with these genes would get HIV or AIDS. Plus the likelihood of these cloned viruses getting anywhere near members of the public would be so miniscule as to be insignificant.
Emily, London, UK
Surely in the instance where a 'father' chooses not to have any involvement in a childs life, a surrogate parent is preferable to an absent one? If two women, or men decide to take on the enormous responibility of raising a child we should give them our support not our ivory tower condemnation.
Siobhan, Dublin, Ireland
They're trying to eradicate HIV by injecting people with it? Oh. My. God.
Lois, Bangor,
Not very re-assuring that these scientists are just like shildren playing with fire.
One also ponders the wisdom of "stitching" HIV into the common cold virus. And they can hardly claim that it's perfectly safe to do it, can they...
Next time you catch a cold you can reflect on what it has stitched in to it, and which laboratory drain it escaped from. We should all sleep easier in our beds, knowing hoe science is looking after us.
And GM crops? Oh, perfectly safe...
Mike Poulsen, Reading, Berkshire