Terence Kealey
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The evil Doctor Venter strikes again. Not content with having stolen our biological past (it was he who patented the human genome) he is now trying to steal our biological future too.
This week it was reported that Dr Venter had created, artificially, the first living copy of a bacterium. In keeping with his sinister reputation, he did not choose a friendly bacterium to copy; instead he copied Mycoplasma genitalium. M. genitalium lives, as its name suggests, in our genital tracts and it is easily transmitted during sex. Currently, it is assumed to be relatively harmless, but who knows what Dr Venter intends to do next with it, was the subtext of some news reports?
On closer examination of Dr Venter's paper, the work is not as dramatic as some reports suggested. He selected M. genitalium not for malign reasons but simply because its DNA is shorter than that of most bacteria. Nonetheless, it still comprises 582,970 chemical units or “base pairs”, strung along as a filament.
And Dr Venter has not yet actually copied the bacterium itself. Instead, he has only synthesised its DNA in the test tube. A number of virus DNAs have already been synthesised artificially, so although the synthesis of the DNA of M. genitalium represents a technical tour de force (it is over 10 times longer than the longest virus DNA synthesised to date) it represents no fundamental breakthrough, biologically. It is not the first living DNA to have been synthesised artificially.
But Dr Venter will shortly turn his DNA into a living breeding bacterium, and because viruses are parasites whereas bacteria can be self-sufficient, he is on the point of creating a life form that can live and breed autonomously.
Dr Venter is a great self-publicist (he announced his achievement at the World Economic Forum in Davos) but he is simply the latest in a long line of biochemists who have punctured life's claims to specialness. Until 1828 it was believed that life, with its so-called “vital forces”, owed nothing to science, but in that year Friedrich Wöhler synthesised urea in the test tube. Since then, chemistry's invasion of biology has been unstoppable.
So it is not science fiction, it is inevitable, that within our children's lifetimes, molecular biologists will tweak the human genome. If we can re-create existing bacterial genomes, we will be able to create new improved human ones. The ills that flesh is heir to are many, but thanks to DNA chemistry they will be abolished. Diseases such as cystic fibrosis or muscular dystrophy will be eliminated as thoroughly as smallpox. And the greatest ill of all - ageing - will also be conquered.
It was Sir Francis Bacon, the Father of the Scientific Method, who wrote in his Valerius Terminus of 1603 that the purpose of science was the “discovery of all operations and possibilities of operations from immortality (if it were possible) to the meanest mechanical practice” - and immortality is possible. We know that some animal species such as the hydra and the sea anemone are apparently immortal, and we are beginning to understand the chemical operations by which they achieve that. Indeed, those mechanisms may already operate within our own testes and ovaries.
So one day a successor of Dr Venter will discover how to render all our cells as immortal as the hydra's or the sea anemone's. That day will see the beginning of the end of cancer, coronary heart disease and the other horrors that are largely caused by ageing, and though it could introduce new horrors such as terminal boredom and the end of inheritance taxes, it will be memorable.
Ageing is a planned process. The main cause is oxygen which, as it is consumed during ordinary metabolism, produces dangerous side-products called free radicals. These side-products cause cancer, atherosclerosis, and - by destroying brain cells - dementia. But free radicals can be countered by enzymes that mop them up. Unfortunately, such damage limitation is expensive in terms of energy.
In his book Time of our Lives Professor Tom Kirkwood explained that evolution trades ageing against speed. Nature realises that the average mouse, say, will live for only two or three years in the wild because it is so vulnerable to predators. But the average elephant will live for half a century before succumbing to a fatal mishap.
So Nature does not provide mice with enzymes to protect them from ageing, because mice will not last long anyway. Nature, instead, provides mice with fast metabolisms, to help them flee danger. Consequently, mice naturally age fast. But elephants move ponderously, because Nature has given them little energy for running around. Instead, Nature pours energy into their anti-free radical enzymes, protecting them from ageing.
Most of us feel that our lives are too short but one day, thanks to the work of Dr Venter and others, we will introduce better anti-ageing enzymes into our DNA. The consequence will be a slower, more chilled species, but we will live longer.
Craig Venter's autobiography reveals a driven man. He expends a lot of energy, so he may not live long. But thanks to him our children will. Not so evil after all.
Terence Kealey is a clinical biochemist and author of Sex, Science and Profits
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Markus, if you want to die, you can die. Me? I'd rather live as long as possible.
WHEN, not IF life extension therapies appear, one presumes you won't be in the queue for treatment?
scott tunstall, Glasgow, Scotland
Couldn't the good doctor simply find a way of redirecting all those calories which are currently contributing to the obesity epedemic into fuelling the body's fight against ageing? He will slash NHS spending, so guaranteeing that money will be able for his own future research activities. Surely Darwinist natural selection at work.
By the way, elephants live to about 50 because after that they run out of teeth, and starve.
Simon, Brussels,
"Ageing is a planned process." "Nature realises..."
Who planned ageing? How can nature (not only inanimate but also abstract) realise anything?
Surely Times readers can grasp the fairly simple scientific concepts that the author describes without needing such childish, anthropomorphic devices.
Unless, of course, the intention is to promote some version of creationism or intelligent design.
Peter Warden, Limoges, France
I think you will find that whilst oxidation is a threat to cells the damage that occurs to telomeres on the end of chromosones when cells divide is the root cause of ageing. The longer an individual's telomeres the longer their lifespan.
It's man's destiny to confront Nature and mess with what he doesn't understand in order that he might - as long as it doesn't kill him in the process. However, the hubris man expresses in the face of billions of years of evolutionary experience is breathtaking. If a long life span conferred an advantage then over those billions of years such an organism would exist. Since the only one I know of that lives to a great age is a tortoise I have to ask the question is being a tortoise an advantage?
This man seeks a financial reward (or rather his commercial sponsors do) by persuading us that we can have a lifestyle reward - that doesn't exist. In return we all face the risk that he will get it all terribly wrong. Deal or no Deal?
Eddie Reader, birmingham, england
Are you crazy? Natural forces have created out of their own powers the wonderful world of life on this planet. The "improvements" of man have greatly harmed the health and diversity of this web of life. Even mankind has not benefitted on a biological level, quite the opposite. And this work of hubris, devoid of any humility, will now result in a panacea? Preposterous. They promise to make an organism that will "eat CO2", thus solving global warming. Those already exist: phytoplankton. Does nobody recall the biological desasters of introduced organisms? Imagine if an artificial microbe with unforeseen capabilities gets loose and multiplies. Remember, the Earth would be covered in a foot of bacteria in 24 hours if their mortality were eliminated. Manmade lifeforms will destroy the 4 billion year old heritage of natural evolution. This must be outlawed immediately. These scientists are no heroes, but perpetrators of the most serious crime against the Natural World and Humanity
Markus Opel, MD, Grants Pass, OR/USA
How else can we travel light years to our new home?
Jesse, carolinalogman@yahoo.com, usa/sc