David Rose
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Nearly 3,000 patients have died in the past three years as a result of taking medicines intended to help them, official figures show.
Thousands more have been hospitalised after suffering harmful side-effects or serious allergic reactions to prescription drugs and other medications.
Almost half of the deaths occurred last year, while the number of reported adverse drug reactions has increased by 45 per cent over a decade. Growing numbers of patients taking aspirin and other medications for chronic illness such as heart disease could be fuelling the trend, experts suggest.
A total of 964 UK patients died because of suspected drug reactions in 2006, more than 200 after lengthy stays in hospital. A further 4,432 patients were also hospitalised but survived, figures obtained by the Liberal Democrats show.
Adverse drug reactions (ADRs) describe the unwanted, negative consequences associated with the use of any medications, as a result of medical error or otherwise. They represent a considerable burden on the NHS, accounting for 1 in 16 hospital admissions, at a cost of up to £466 million a year.
Patients admitted because of ADRs stay an average of eight days in hospital, research suggests, meaning that at any one time they take up the equivalent of up to seven 800-bed hospitals in England alone. Over the past three years, 2,846 patients died as a result of a suspected ADR, while 13,643 patients were hospitalised, the figures show.
Drugs most commonly implicated in adverse reactions include low-dose aspirin, diuretics, the anticoagulant drug warfarin and other nonsteroidal antiinflammatory drugs.
The most common problem associated with these medications is gastrointestinal bleeding, which can be fatal. But many of the reactions were likely to be because of incorrect dosages or known interactions of the drugs and as such were avoidable, research suggests.
The latest figures were revealed in answer to parliamentary questions by the Liberal Democrats. Norman Lamb, the party’s health spokesman, commented: “This is a dangerously escalating problem, which is putting lives at risk and placing a big cost burden on the NHS.” In addition, new “treatment targets” for specific long-term diseases, such as high blood pressure or high cholesterol, are likely to lead to more patients taking medicines with possible interactions and side-effects, he said.
Approximately 20,000 reports of adverse drug reactions are made to the Medicines and Healthcare Products Regulatory Agency and Commission for Human Medicines every year through a spontaneous reporting system known as the “yellow card” scheme. But Dawn Primarolo, the Minister for Public Health, admitted that the yellow card scheme “is associated with an unknown level of underreporting”.
“In addition, it is important to note that the submission of a suspected ADR report does not necessarily mean that it was caused by the drug,” she added.
But the Government’s Chief Medical Officer said that the NHS could be better at learning from its prescribing mistakes. At a conference held by the National Patient Safety Agency last month, Sir Liam Donaldson said that drug allergies were a significant cause of avoidable harm in hospitals. He has also recommended that NHS organisations should be fined if patients are harmed while in their care.
“When someone has a known allergy and we give them the drug in error or a lack of awareness as to what’s being prescribed, the results can be fatal,” he said. “Although these are not common events, some mistakes are capable of being repeated and we have to become better at learning from these mistakes.”
Sir Liam recalled the case of Teresa Innes, 38, who lapsed into a coma in September 2001 after a surgeon at Bradford Royal Infirmary prescribed a drug containing penicillin as she was about to undergo a routine procedure to drain fluid from an abscess on her thigh. Despite wearing a red allergy band on her wrist and medical notes giving warning about her acute aversion to the antibiotic, Mrs Innes was given the drug Magnapen, which staff did not realise contained penicillin.
The former care worker suffered an-aphylactic shock, which stopped her heart for 35 minutes, resulting in permanent brain damage. She was left in a persistent vegetative state from which she never recovered. She died two years later.
Sir Liam added: “This is a tragic and avoidable case.”
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Unfortunately, medical myths flourish when the remedy earns drug companies multi-$-bllions. An example is the cholesterol myth. Please read the following texts which have examined many hundreds of original research reports (not selective, biased reviews or self-fulfilling "meta-analyses"): Ravnskov, U. The Cholesterol Myths: and Duane Graveline; Lipitor - Thief of Time; both from http://www.Amazon.co.uk; Colpo, A. The Great Cholesterol Con; ISBN 978-1-4303-0933-8 from http://www.lulu.com ; Kendrick, M. The Great Cholesterol Con, ISBN 978-1-84454-360-1; McCully, KS. "The Homcysteine Revolution", ISBN 0-87983-975-9.
Homocysteine is particularly interesting as it is far better marker of atherosclerosis and can be reduced by folic acid, B6 and B12. But this is NOT GOOD for big Pharma, the "opinion-makers", donations receivers and researchers. No profit in the remedy!
M. Cawdery, Portadown, UK
I have suffered adverse reaction to two different prescribed medications. On one occasion I was ridiculed, on the second occasion the GPâs reaction was to shout in my face!
Disgusted , Cheshire , Cheshire
I suppose my dr thinks he is trying to help me but I have several conditions I'll never get over despite his so-called "help."
This is not ALL his fault. He was taught that if a patient is ill the thing to do is to treat symptoms, not illness. He was taught to prescribe drugs that only mask symptoms.
He was taught NOT to listen to patients. He was taught NOT to do research into a particular patients' problem. He was taught TO ridicule any patient who dares question His Authority by going to the 'net and looking up the latest Fave Drug.
He was taught to run roughshod over patients' protests regarding allergic reactions to drugs. He was taught that patients don't know anything about themselves & his job is to keep it that way.
The fact he was not taught properly, well, that just doesn't matter as long as his bank account grows daily. Yes, folks, it's all about the $$$.
He treats me with drugs made for illnesses I don't have. I worry I'll get some other illness & die from his "help.
Jay Morgan, Clearlake Oaks, CA
Keep away from pharma is my motto. Take care of your health, don't overstress it and don't expect pharmaceuticals to bail you out. Seek help from alternative therapies before you develop serious symptoms - homeopathy, acupuncture, traditional chinese medicine.
Alison Robinson, Reading, UK
I am also allergic to antibiotics and some other substances. I have Stevens-Johnston Syndrome (SJS). This is clearly stated on my notes and my wrist and ankle bands when I am in hospital. So far in 2007 I have been written up for penicillin 12 times but 9 different doctors in 4 different hospitals AFTER I have told them all more than once about my SJS. When I refuse to take drugs the staff write up a refusal and tell me I am unco-operative.
Mt last admission was as a emergency. Anti-biotics were prescribed. I didn't take them and told the staff why, thy looked at my notes and said I should have been issued with a red band. I had red bands on my wrists and ankles - all on full view as I was naked..... The doctor refused to come back to check the prescription and I was discharged from hospital within an hour with no further treatment. I still have the problem that put me in hospital. An complaint is being persued by the ombudsman but I doubt if anything will change.
Patch , Galashiels, UK
I never heard of an allergic reaction to a safe effective inexpensive homeopathic medicine. And it cleared 30 years of my psoriasis in 3 months, later on dealt with septicaemia and peritonitis, and cracked my kidney stones. Longer lives through homeopathy which has seriously improved my health
Francis Treuherz, London, England
Again let's have a go at the pharmaceutical companies, yes they make a profit, but who in business doesn't.
When you consider though that AstraZeneca spend $16 million every day on research, they need to make a healthy profit.
Mike Jones, Swansea, UK
It is the fault of the pharmaceutical industry who have been the subject of a government investigation into their influence; The government who have taken little notable action on the investigations results â other than to use the unfavourable findings to negotiate lower prices for the most commonly prescribed drugs including blood pressure, cholesterol and antidepressant medications â making it appear that influence & prescribing has been curtailed as net costs have reduced; And the medical profession who are gullible & complacent enough to believe the incomplete manipulated (as verified by the government investigation) pharmaceutical industry study results they are fed as irrefutable proof of a drugs efficacy & safety, seemingly with the government and health authoritiesâ blessing because of the revenue they generate. As the yellow card ADR reporting system is voluntary -- if recognised and acknowledged at all -- true numbers of adverse events will never be accurately recorded
Mardi Bennett, Colchester, Essex
In the case of these 11 previous comments, how many, would you like to guess, are corporate shills? Doctors have good intentions and 99% of them go into medicine wanting to help people. Corporations are not human and only have only the incentive to make profit. And yes, we all know that humans run the corporations. Our evil reptilian overlords will be overjoyed with your delusion.
George, Nagoya, Japan
The pharmaceutical companies are the most profitable companies in the world by a huge margin. They make these profits by selling dangerous chemicals to people on the premise that they will benifit your health. In the vast majority of cases the damage done greatly outweighs any benefits.
Google for a book called "Rockefeller Medecine Men" and learn the truth about the criminals who run the Pharma Companies.
Ben, Leeds,
I am a science student fully aware of the need to test medicines in animal models. Sorry if it sounds controversial but I hope that people like Jennifer Hynes don't ever take any paracetamol, pain killers or suffer from anything worse so she has to take medication. If it wasn't for animal models and the extremely well regulated testing, there would be many more people dying.
Or do you suggest that medicines are taken away all together?
The reasons why people die when taking medicines is due to genetic differences and interactions. Believe me, scientists are working hard on it, not moaning about it!
Cris, London,
I work for a pharmaceutical company and deal with reports of these adverse events. Nearly all of the serious ones are caused by errors on the part of the doctors. They prescribe drugs needlessly, but more worryingly they prescribe the wrong medications for the illness they are trying to treat and even more worryingly they prescribe drugs to patients with conditions that are dangerous when these drugs are taken, and they prescribe mixtures of drugs even though these drugs are known to cause serious interactions. This is not the fault of the companies because they make doctors and hospitals aware of these facts, but the doctors just do not seem to care because they face few repecussions. Recently I found out that a doctor had prescribed a certain drug to treat diabetes even though this drug is not meant to treat diabetes and carries a warning stating that diabetics should not use this drug! The patient nearly died!
anon, Europe,
The increasing use of generic preparations could also have a bearing on this problem. There is increasing evidence that some generic preparations are not of equivalent therapeutic efficacy when compared with the proprietary product.
The problem is compounded as many active ingregients and excipients are manufactured in the far east and it is dificult to ascertain the complete formulation of many products.
Compounding ,packaging and marketing may all be done in different countries making comparison between products almost impossible, particularly as the same manufactured product may be marketed by several different companies.
It is therefore difficult for a patient to be aware if the preparation contains anything to which he or she is allergic and the generic brand is changed on a regular basis.
Laurie, Faro,
Medicines are over prescribed the Government should be looking at ways to stop prescribing these medications as apposed to prescribing them which as we all commonly know cause more harm than good. Its time this Country wakes up and gets to grips with these matters. For the amount of complications they cause from all the news we here it hardly seems worth giving out the medications in the first place and im sure a lot of people believe this is true
Matthew, Bradford,
This is hardly surprising given that they are tested and declared safe on non-humans... when will science learn? To abuse other creatures for our own purposes is immoral and just plain wrong, and of course, we read things like this.
Jennifer Hynes, Plymouth, England
Last week I was called to my GP to discuss my osteoporosis medication - strontium ranelate (Protelos). I was informed there had been a report of deaths as a reult of taking this and was consequently advised to stop taking it until I had discussed the risks further with my Consultant in March 2008.
If anyone seeing my comment is taking this medication I wld recommend querying it with their GP/consultant.
Jan, Hove, UK
This year I went into an NHS hospital and had two red wrist bands put on to boldly signify that I was allergic to penicillin. After three identical interviews from a nurse, a junior doctor and a consultant I was given a large dose of what I found out very soon after to be penicillin and spent the next 10 days with the entire surface of my body red raw when my skin erupted totally to the concoction. I could barely move.
Don't blame the medicine when it is used in error.
jj, Cambridgeshire, UK
964 is not 'almost half' of 'nearly 3000'.
Rob, Reading, UK
This is all very well.....but people neglect to tell you HOW MANY lives are saved by taking these drugs.
As normal its a politian scoring points by frightening the populus.
The adverse effect from NOT taking such drugs as Aspirin in most cases is suffering a clot, I think most people know the adverse effect of a clot......you become a politian...
Karen, Brighton, Sussex.
I am a coeliac and I must not eat the gluten found in wheat, barley and rye.
If I buy a prepared meal from a supermarket, it is clearly marked if it contains gluten and I know whether it is a safe purchase. I believe this is the law.
But if I go to a pharmacy and buy say a cough syrup, I have no idea whether it contains gluten. And in many cases neither does the pharmacist, despite the best of their efforts.
All medicines should contain details of the allergens they contain. If they can do it for food, they can do it for medicines.
James Miller, Newmarket, UK
It is recorded that when the doctors in Canada went on strike many years ago the death rate went down.
The drug-chemical industrial complex have a vested interest in keeping people sick because they make money out of it.
I once heard that ICI are one of the UKs' main manufacturers of carcinogens. They are also one of the main companies manufacturing anti-cancer drugs. Every cancer patient earns them £70,000 per year at least.
They are not in business out of the goodness of their heart, They are there to make money.
Hopefully one good thing about the EU is that companies will be accountable at last.
Keith B, Wigan, UK