JUNK MEDICINE: MARK HENDERSON
Win VIP tickets
In the 30 years since Louise Brown became the first test- tube baby, fertility treatment has come so far that it now accounts for one UK birth in 100. Yet there are still patients for whom it can do little. Men who make no sperm, and women with no eggs, must rely on adoption, donor conception or surrogacy if they want to start a family. That situation, however, may soon change because of advances in stem cell research.Sperm grown from embryonic stem cells have already been used to produce mouse pups, and scientists are trying to use similar techniques to make human reproductive cells, or gametes. This week, the Hinxton group - a panel of stem cell experts - predicted that success could be as little as five years away.
The next step would be to make “artificial gametes”. Cells from an infertile man or woman would first be reprogrammed into an embryonic state, or used to make cloned embryonic stem cells. The resulting stem cells would then be turned into sperm or eggs, which would carry the patient's DNA.Many of those this technology would benefit have survived childhood cancers, diagnosed when they were too young to freeze sperm or eggs to preserve fertility. Others are women who have suffered the distress of early menopause. This is medical science at its compassionate best.
Not everybody, however, has seen it quite like that. Whenever new developments in this field are reported, they invariably prompt speculation that the technique might be used to allow lesbians to produce sperm, and gay men eggs. Homosexual couples might thus have a child with genetic material from both partners, in a way that is unthinkable in nature. Worried discussions about what this might mean for sexual politics often drown out dialogue on the benefits for infertile patients.
The Daily Telegraph, for instance, reported the Hinxton group's findings on Tuesday under the headline: “Same-sex couples could produce children”. That was strange considering that the Hinxton scientists actually took pains to point out that this is not going to be on the agenda any time soon. Our sex is determined by the inheritance patterns of the X and Y chromosomes: women have two copies of the X, while men have one X and one Y. This is critical to the formation of gametes, and will make it very difficult to create them from cells of the opposite sex. As eggs are more complex than sperm, experts think it will be hard enough to make them from XX stem cells, let alone from male ones. And as working sperm require genes on the Y chromosome, which female cells lack, it will be even more problematic to produce them from women - many scientists even think this impossible without extensive genetic engineering.
This distraction would not much matter but for the way it is influencing debate about the Human Fertilisation and Embryology Bill. This new legislation, which reaches the Commons next month, will allow research into artificial gametes, while outlawing their use in fertility treatment. Such a ban is fine for now as this technology has not yet been developed, never mind proven safe. Scientists and patient groups, however, have proposed that Parliament should have a “regulation- making power” to approve clinical use in future with a vote, should evidence suggest it looks safe enough to try.
This would be a sensible measure. As the Bill stands, fresh primary legislation would be needed before patients could benefit, which could take years to reach the statute book. Yet the Government has so far rebuffed attempts to amend it, largely because of controversy about same-sex parents. If it were possible, the prospect of female sperm and male eggs would indeed be a proper subject for public consideration. But it is not, nor is it likely to be in the forseeable future, and the ethical questions raised have little bearing on helping the infertile to reproduce.
Mark Henderson is the Science Editor of The Times
Win a luxury weekend to Newcastle and its neighbour Gateshead, find out more here
Risk, resilience and embracing new technology
Industry sectors news at a glance. Interactive heatmap, video and podcast
Discover the power of collective thinking. Submit a solution and be in with a chance to win a Media Hub Home Entertainment System
The inside track on current trends in the charity, not for profit and social enterprise sectors
Everything the Business Traveller needs to know to make a better trip
Make the most of the summer and enter our fabulous photographic competition, you could win a £5000 holiday
Corsica is an island of beauty and contrast, an ideal holiday destination
Enjoy further reading from Travel to Fashion, Business to Sport, discover more




Shortcuts to help you find sections and articles
The clever way to lease a new car is with Car leasing made simple™
2009
per month on 36-month
Personal Contract Hire (PCH)
2008
42850
Car Insurance
£23,093 - £56,211
The Office for National Statistics
Newport, South Wales
£60,000
The Environment Agency
Bristol
Up to £90K
Boots
Midlands
OTE £85k
Credit Protection Association
Nationwide Opportunities
Completely London
Luxury Condo's in Manhattan with NYC views
The best new homes in Wimbledon?
Nationwide
Fabulous Cruise And Cruise & Stay Offers Including Virgin Atlantic Flights Prices Start From Only £699pp!
Last Minute Cruise And Cruise & Stay Offers. Med From £499pp, Caribbean From £699pp!
5 star quality at a 3 star price.
8 fabulous Canadian cities ...you won’t find cheaper
Contact our advertising team for advertising and sponsorship in Times Online, The Times and The Sunday Times, or place your advertisement.
Times Online Services: Dating | Jobs | Property Search | Used Cars | Holidays | Births, Marriages, Deaths | Subscriptions | E-paper
News International associated websites: Globrix Property Search | Property Finder | Milkround
Copyright 2009 Times Newspapers Ltd.
This service is provided on Times Newspapers' standard Terms and Conditions. Please read our Privacy Policy.To inquire about a licence to reproduce material from Times Online, The Times or The Sunday Times, click here.This website is published by a member of the News International Group. News International Limited, 1 Virginia St, London E98 1XY, is the holding company for the News International group and is registered in England No 81701. VAT number GB 243 8054 69.
What about in the case of people who were born female but have the XY chromosome pattern, (who have conditions like Androgen Insensitivity Syndrome/Testicular Feminisation or 5-alpha reductase 2 deficiency), who might want eggs though they never made them naturally? There are other conditions where a female can be XY or just have a single X chromosome (such as in the case of Turner Syndrome). There are also conditions where a male can be XX or even XXY, and they might want sperm though they never made it naturally. These people can be heterosexual but naturally sterile but might strongly desire to have a child too. Should they be offered this treatment if it is possible in a few years? Having said that, I think adoption/fostering is a good thing to do for children in need, and I admire people who do it. I personally would feel better about myself if I adopted or fostered, because then I would know I'd helped someone.
Lucia Strong, London, England
At least for female sperm, the required genetic engineering is not "extensive", if you understand current techniques in chromosome manipulation. For example, one can use the well-known technique of microcell-mediated chromosome transfer (MMCT) to add a Y chromosome to a female germ-like cell on its way to become a sperm. For more information on the probable creation of human female sperm (already achieved in chickens) within the next five to ten years, check out: www.samesexprocreation.com
Greg Aharonian, San Francisco, CA