David Rose
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Nicotine can be good for the brain, research suggests, and its effects could form the basis for new drugs to stave off Alzheimer's disease.
Smokers may already be familiar with the mental “buzz” from nicotine but researchers from King's College London found that in rats it improved their learning, memory and performance on cognitive tasks by up to 15 per cent.
Scientists pointed out, however, that the effect was very small and the health risks of smoking and toxic effects of using nicotine patches would outweigh the benefits in healthy people. Pharmaceutical companies are hoping to amplify the positive effects of nicotine to benefit dementia patients, while minimising the risk of addiction.
Nicotine acts on various receptors in the brain to produce a stimulating and also addictive effect. In research to be presented at the Forum of European Neuroscience in Geneva today, the King's College team found that injecting the rats with nicotine produced improvements in sustained attention and reactions to visual stimuli by 5 per cent.
When the rats were distracted with flashing lights and sounds, the concentration of those who had been given nicotine improved by 15 per cent compared with a control group.
Ian Stolerman, from the Institute of Psychiatry, King's College, said he was surprised to find beneficial cognitive effects but added that they were very small. The differences between doses that produced cognitive and toxic effects were also small and, significantly, there was a high risk of addiction.
He added that nicotine was difficult to administer in significant non-harmful doses by conventional means, such as a patch or inhaler.
Drugs based upon the chemical structure of nicotine are already in phase 2 trials to see whether they can forestall the mental decline of Alzheimer's patients. It is thought that the drugs may allow the patients to remain alert and retain their memory for slightly longer.
Professor Stolerman said that there might be side-effects. “We found several similarities and only small differences between the cognitive mechanisms and those involved in the addictive effects of nicotine. The cognitive ‘boost' that many smokers experience from nicotine probably contributes to the reason people smoke cigarettes, so it may not be possible to totally prevent addiction.
“Nevertheless, the potential for abuse of a medicine based on a pure nicotine-like substance is likely to be very small.”
Studying the mechanisms of nicotine action may speed the discovery of more effective cognitive enhancers than nicotine itself, with longer-lasting effects. “This is a promising stage in the years of research,” Professor Stolerman said.
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I find it hilarious really.
All of you point to smoking and dip and snuff and chew and what have you..... You have all FAILED to mention electronic cigarettes.
Nicotine without the tar and hazardous additives.
I vape on an E-cig and LOVE it! You should try it too!
Static, Chattanooga, USA
My mother died of Alzheimer's after a 12-year period of hell. I assure you that I'd much rather die of cancer than Alzheimer's. Although I've never been a smoker, I'm considering taking it up when I'm about 65 years old to deter Alzheimer's. It's a no-brainer to me.
sharon adams, Atlanta, USA
Yes Peter not ever smoker ends up with cancer but a vast number do and a number who avoid cancer succumb to heart disease or the various respiratory diseases. 3 of my grandparents smoked - all three died slow and painful deaths before 65. The benefits are negligible.
Simon, cambridge,
Virginia: you can take in nicotine without smoking. There are various forms of smokeless tobacco, including snuff; or things like nicotine chewing gum or patches.
Joe Cremona, Chester, UK
it is very old information and only now it comes out:(
marry, london, uk
The UK pharmaceutical company Meldex International is launching (initially in Poland) a dissolve-in-the-mouth film strip that gives an instant hit of nicotine similar to a cigarette. This means it doesn't have the bad effects caused by inhalation of smoke. Perhaps this product could help here.
Baton, Nelson, New Zealand
"Non-smokers die every day...Enjoy your evening. See, I know that you entertain this eternal life fantasy because you've chosen not to smoke, but let me be the first to pop that bubble and bring you hurtling back to reality....You're dead too. .."
Bill Hicks, Heaven,
One small factual error: nicotine acts very specifically on nicotinic acetylcholine receptors not "various receptors in the brain".
Mick, Edinburgh,
i was not trying to claim that smoking was benign in any way. the article was about the potential benefits of nicotine, not the positive effects of smoking.
and will you kind of made my point with "Bear in mind that half of all smokers die of smoking related illnesses." that's half not all then!
pete woodhouse, edinburgh, scotland
Only a minority of smokers end up with cancer & many ca. patients have never smoked.How long before someone comes out and says "smoking [in moderation] is good for you"?I remember a time when a GP recommended smoking, to relieve bronchial congestion! Good for relieving constipation too!
patricia, Kent,
People may perceive that "absolutely every smoker does not end up with cancer" - for many people the vascular complications like stroke, heart attack, leg or gut ischaemia get them before cancer does. Not to mention chronic lung disease. Smoking kills; but not everyone has the insight to see this.
Scott, Glasgow,
Pete:
I think Virginia's point is quite clear.
Bear in mind that half of all smokers die of smoking related illnesses.
Put that in your pipe....etc
Will Ockendon, Wellingborough, UK
So at least you'll be able to remember how you got cancer!
Kevin Browne, Reading, Berkshire, England
My grandmother has been smoking 20-a-day for as long as I can remember (I'm now 24).
Unfortunately her own monther suffered from dementia and it seems like she is now going the same way. So based on that evidence I would say that any potential benefits would appear to be minimal.
Michael, Welwyn Garden City, UK
Long been known that Nicotine has positives - but terribly politically incorrect to mention the benefits - upsets the anti-smoking zealots.
Possibly Virginia might consider Japan - heaviest smokers and boasts the worlds longest lifespan.
Ivan, Coleraine,
Nicotine mimics the neurotransmitter acetylcholine, thats why smoking has neurological effect, and its been noted that smoking nicotine reduces the effect from some dementias. The problems with smoking it are the carcinogens in smoke.
James, Chelmsford, UK
absolutely correct virginia, however we're not talking absolutes here are we. absolutely every drinker does not end up with cirrhosis of the liver, and absolutely every smoker does not end up with cancer. so your point is?
pete woodhouse, edinburgh, scotland
What is the good of having a good memory but body ravaged by cancer which is no doubt caused by smoking!!
virginia, Brisbane, Australia