A drug injected into the spine has produced rapid improvements in verbal fluency in a trial of 12 patients with Alzheimer’s disease.

Etanercept (Enbrel), an antiTNF drug developed to treat rheumatoid arthritis, transformed the behaviour of some patients in a matter of minutes, the researchers say.

The results, published in BMC Neurology, are the latest in a series of bold claims made by Edward Tobinick, from a private medical group in Los Angeles, and Hyman Gross, of the University of Southern California.

Their theory is that TNF is used in the brain to regulate the transmission of nerve impulses. They say that in Alzheimer’s high levels of TNF interfere with this process, so suppressing TNF with Enbrel should cause a reduction in Alzheimer’s symptoms.

BMC Neurology is accessible on the internet and includes a video showing the rapid improvements in language skills. Dr Tobinick said: “There are limitations to the data presented; the clinical trial was open label and not controlled. These caveats notwithstanding, the scientific rationale for the further investigation of antiTNF treatment of Alzheimer’s disease is compelling.”

Alzheimer’s experts have been sceptical of Dr Tobinick’s research. They say that Enbrel, even when injected into the spine, might not reach the brain in sufficient quantities to have any effect. Dr Tobinick has called for a full-scale trial of his methods.

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