My wife has had alzheimers for over 4 years. She is on aricept and namenda, losing more memory every day. We have nothing to lose by trying any new clinicle trial for a promising new drug, nothing to lose! Please release the new drugs,please.

Howard Eppley, Inverness, USA

My 83-year-old mother was diagnosed with AD last year. She is on Aricept & Numenda. The Numenda slowed down the progression, but now I am noticing a significant change. She is losing more & more of her memory. Please get this drug on the Market in the US. Mom will die without help.

Chere Hallahan, Ashland, Kentucky, USA

I am almost 62 years old but can easily pass for early fifties and work out regularly. I am doing very well except for my Alzheimer's Disease. If Rember is showing these great benefits it is a shame or even a to tragedy to not make it available as soon as possible. I am not alone.

Edward F. Sorensen III, Frederick, USA

My Husband was 58 whwn in 2006 AD was diagnosed. Is there a way to get the drug rember or urulene blue or to be put on the studies or trials. We live in Hamburg, Germany.

Dorothea Lörz, Hamburg, Germany

My wife who is 76 has been diagnosed with Alhzeimers/Dementia about 2 years ago She was put on
Risperidone for about 20 months and Ebixa (MemantineHCL)for the past year. This was replaced 2 months ago with Exelon (patch 10) . No significant changes yet. How can she get on the Rember trial list?

Daniel Wallace, Keilor Downs VIC 3038, Australia

My mother is 81 and has been diagnosed with early AZ. How can we get her into a clinical trial of Rember? Please advise.

Linda Van Dam, Mission Viejo, USA

On the market now from Regen Therapeutics - a recent news item:
Professor Kruzel: ... low dose of Colostrinin can favourably modulate the expression of several molecules involved in the pathology of Alzheimer's disease ... data suggests that it may impact both Tau tangles and beta amyloid plaques

mike, Gloucester, UK

My father has been diagnosed with Alzheiner's five or six years ago, He has anger spells because he don't know how to communicate it causes the family to anger.We need help here in USA. How can he get on the list Rember trial?

Quinetta James, Jonesboro, USA

My Mother and grandmother had Alzhiemers. I am 56. My Mother is 86 and still knows me some days. Can I get her on Rember? How will I know when or if I need it?

Evelyn , Macon, GA, USA

My Mother and grandmother had Alzhiemers. I am 56. My Mother is 86 and still knows me some days. Can I get her on Rember? How will I know when or if I need it?

Evelyn , Macon, GA, USA

My husband was diagnosed with Alzheiner's in Feb. 2007. He has been taking Namenda & Exelon since that time & is doing quite well with no side effects. Are there going to be any trials in the USA and if so, how can we can register him for the Rember trials? Progression has been slow.

Kentucky

Shirley Burns, Richmond, USA

Are there any trials of Rember scheduled to be run in Canada? How would you get into the trial? My mother has been taking Aricept for a year with so negative side effects and this would be a better alternative

Jim Quinn, South Elgin, USA

my wife was diagnoised 12/2006 with mild to moderate she was taking aricept the first year and nameda was added the 2nd year.she was a office manager for 16 years for a doctor.amazingly sharpe at the time.i still see she is not slowing the progression. is a study avaiable for rember tin the states.

randoe, athens al, usa

My husband was diagnosed with early onset of Alzheimer's in 2002 at age 59 when we were in California, USA. we are now living in Botswana, I am wondering how I could register him for rember trials.

Moetse Maher, Gaeage, Maun, Botswana

My mother has been diagnosed since July 2003 and now progressed into stage two of the disease. She has been taking Exelon for 4 years and recently was prescribed Ebix. How can I get her into a trial with Rember? She was 74.
I thank you very much.
Monica Pires do Rio, Rio de Janeiro, Brazil

Monica Pires do Rio, Rio de Janeiro, Brazil

My husband 70 years old from israel worked almost until the last months as an engeneer The problems began 2 years ago, after heart operaition . He had been diagnosed a year ago with Alzheimer and generally he is a fighter
I hope he would take part in the trial of rember

Rosenfeld, Hod hasharon, Israel

My mother has just been diagnosed with Alzheimer's - like everyone else here in the same situation, 2012 will be too late - how do I get her into a trial now? What have we to lose?

Michele Wright, Ferryside, Wales

My father has recently been diagnosed with the beginning stages of Alzheimers. I would love to see him included in a trial for Rember. My prayers would then be answered. He is only 64.

Sheryl, Grande Prairie, Alberta, Canada

Just read all the comments of all the people in my same situation. Desperate to help a loved one from the brutality of this disease. I like all the rest want to know how I can get my mother into a rember case study. 2012 will be to late...

Lisa Jones, Chipley, Florida,

My husband was diagnoised with Alzheimers about 5 years ago, just after we were married. For the last almost 3 years he has been on the Flurizan Study with Myriad Genetics. This study was just discontinued. How do we get my husband on this drug. Is there a study to join?

Cindy Houston, Salt Lake City, Utah, USA

i was recently diagnosed with the beginning stages of alzheimers by my Neurologist . I have been a insulin dependent Type 1 diabetic for the last 37 years , since i was age 31. I would be a willing candidate for the study, for myself and for all others who need help. Thanks

Don Roza, Ocala, Florida, United States

Do you have a clinical study for persons with early onset AD that has progressed into late stage 2 or further? What info do you need for patient info to get into a clinical study, or how far is too far into the progression of the disease? Any help we can get is so greatly appreciated. Thank you

Joannie, Jonesboro, United States

My wife, Marion is 77 and suffers from vascular dementia with ever worsening memory problems as the result of a mini stroke in 1999. I am very keen indeed for her to be able to participate in the next series of trials of the new drug rember. How do I go about applying?

Frederick M Rawson, Reigate, Surrey, United Kingdom

My husband is 83 and extremely healthy except for the loss of his short term memory. I would be interested in enrolling him in a clinical study in or near Cleveland.
T. Krill, Lyndhurst, OH

Tanya Krill, Lyndhurst, USA

My wife is 57 and was diagnosed with early onset AD in May of 2007. She has since progressed into stage two of the disease. She has been taking Exelon for over a year now and recently was prescribed Namenda. How can I get her into a trial with Rember? I am desperate to find her help!

Kent Bugg, Pasadena, Maryland, USA

My mother is 88 and is in the later stages of alzheimers. She still perks up when she hears her children and husbands voices. I hope there are plans for a clinical trial in Canada. My dad, an eternal optimist, who at 92 still works everyday visits her daily and holds out hope there will be a cure.

judy Brown, toronto, canada

My husband has been diagnosed with Alzheimer's. Is now "moderate" Alzheimer's. Can he join in the next study coming up? It wouldn't hurt him...it might help! He is on Namenda and Razadyne, but I don't see any improvement, or halting of symptoms. We live near Milwaukee, WI.

Mary Ellen Schmidt, Milwaukee, USA

My father is 80 and has early onset Alzheimers. Most of it is manifested in short term memory. He has responded well to namenda and his memory is stable currently. He still lives on his own and works out at the gym 2-3 hours every day. Is there a Rember clinical trial planned for America?

Tommie Jean Marzol, McLean, USA

My husband was diagnosed with Alzheimer's in 2002 at 59 and is 0n Namenda/Memantine. I would like to know how and whether he could be put on Rember trials.

Moetse Maher, Gaeage, Maun, Botswana

Your article on Rember and all the comments I read with interest. But some time ago I watched a health programme on tv which claimed that dementia was not caused by plaque on the brain but by inflammation and by taking Ibuprofen infflammation of the brain cells could be stopped.

H. Wooler, Rösrath, Germany

My farther has moderate Alzheimers he is 59 i would like any info on who to contact to include my dad in the clinical trials for Rember. He was perfect 3 years ago ,but now he struggles with simple daily tasks. Its a big impact on us all and heart breaking to see my idol decline so please help me.

Ishwinder Bharaj, Bradford, England

My husband is only 53 years old and was diagnosed with moderate Alzheimers. Is there any study that we could get involved in to stop the progression since he is so young?

Deborah Muntean, Chester Springs, USA

Is it possible to buy this drug privately ? I would like to use it on my wife, before it is too late.

alan bradbury, kidderminster, england

Funny, but I thought this is basically an old drug called mentylene blue often used to treat urinary tract infections at a pretty low cost. So perhaps you may want to fake a urinary tract infection. I'm sure it will be much cheaper that way.

roberta l copeland, Loogootee,

My wife, age 79, otherwise of good health has alziemers or a memory loss. MRI did not show any damage to brain cells however memory is failing fast. Is there any way she could be included in one of the trials? We would be willing to travel to Europe is necessary. Please let me know. John Wilson

John Wilson, Olympia, Thurston

My father has Alzheimers and I would like to know if there is
any way that he can participate and take Rember on a trial
basis ?? He is a retired physician and it really bothers me to watch his decline as he was always a very sharp person.
I have been taking care of him for two years.

Chris Perkins, West Hartford, Ct, United States

Does anyone know how to be included in these medical trials, my mother has Alzheimer's.

B Tyler, Wisbech, England

can this drug be legally purchased anywhere in Europe ? are there trials anywhere in Europe ? Is the drug available on the internet ? Cost ? Are there similar drugs ?

Liz Krause, Frankfurt, Germany

My mother has been diaognised with Alzheimer's in the last year. My aunt, her sister, had a similar prevailing condition about 10 years ago.
Is there any chance that she could be considered for a clinical trial on rember?

With best wishes

Suresh Nandha

suresh nandha, kingston upon thames, united kingdom

Do half of these people work for NICE or something? Of course it's motiviated by money. They're in the pockets of politicians, the more money they save, the more rewards and bonuses they get!! There's nothing altruistic about their decisions at all.

Paul Downes, Milton Keynes, UK

i suffer terribly from smoking induced emphysema and i wish someone would find a cure for this.emphysema is the 4th largest killer. imagine breathing in then closing your nose and mouth and trying to breathe in.that is how i feel despite all the medication and physiotherapy.

sohrab, mumbai, india

My father has alzheimer's and it is heartbreaking to see this lovely man affected with this cruel disease. In my view it is a living death and we are losing my father a little bit every day.
A cure or a treatment for this awful disease would be a great gift for the victim and the family.

Karin McClurg, Annahilt Hillsborough, N.Ireland

This drug needs to be tested for use in Down Syndrome. My
fifteen year old daughter suffers from Down Syndrome and there
is nothing to help her. Unfortunately, Americans consider abortion to be a cure for her disease.

Maryellen Gross, West Bloomfield, Michigan, United States

My mi is 62 and she has been diagnosed with Alzheimers almost 10 years ago. I have been reading your comments and I hope that when she sees the Neurologist she is better, I want the best for her - whatever the cost!. Like Stan says by 2012 she is going to be out of criteria. Worst in my country.

Julie León, Bogota, Colombia

a person in the later stages of Alz can not be harmed by using this drug .why can't we permit other doctors and patients to be a part of a wider test . by2012 my wife may be dead.

stan kowalski Long Beach , Indiana , USA

stan kowalski, Long Beach , In., USA

My dear Mum is only 62 and she has just been diagnosed with early onset moderate Alzheimers. I have been reading all your comments and am hoping that when she sees the Neuropsychologist he is as 'NICE' as he possibly can be because my 4 sisters and I want the best for our Mum - whatever the cost!

Caroline George, London, England

Alzheimers is one form of senile dementia. 'Mini-strokes' syndrome within the brain is another common form of dementia.

Jack Hubbard, Sr., Portage Indiana, USA

I hope the last fase of the clinical trial pases through but is hard to believe on the good news when every week in and out breakthrough is claimed in clinical trials but than all dies down into nothing because all these test tent to fail on tha last fase.

Lec Neli, London, United Kingdom

Hasn't Alzheimer’s become the mis-used euphemism for Senile dementure? I thought the original diagnosis by Alöis Alzheimer was specifically for patients suffering presenile dementia, i.e. 45 to 65 years old. Doesn't anyone get diagnosed with senile dementia any more?

Declan, Sandhurst, Berkshire

I work in drug development and my opinion is this: NICE assessments are based on a number of things, not just cost, but overall benefit and value. If this drug is this good, it will get approved.
However, it will not be incredibliy cheap - the company still has to recover research costs.

Jemma, harlow, UK

NICE have the unenviable job of ensuring maximum healthcare benefit is gained for the highest number of people, from limited funds. If trial stats are accurate, side effects acceptable and Rember cost effective, NICE will respond positively. Wake up, you're not being maliciously denied useful drugs.

Lindsay, Brighton,

What with the threat of immortality and this, the streets of this country will be full of old people who do nothing but have cups of tea and go to the toilet a lot. For God's sake keep these advances away from the likes of Mick Jagger. There's a time to live and a time to die.

Kevin Straw, Leicester,

"Don't for one minute think that NICE will approve this drug for us peasants."

rubbish- on grounds of cost, rember will be incredibly cheap.
rember is methylthioninium chloride, also known as methylene blue which is a common analytical dye. analytical grade material is less than a dollar per gram.

Dave, Manchester, UK

Chippy75: you are not only chippy in every sense of the word, but misinformed. NICE recently passed a new drug which halts wet macular degeneration and my 87 year old mother is benefiting from this.

Dectora, London, UK

I totally agree with Paul's comments. "NICE" never allow any useful drugs to be used, especially it would seem, for the problems our older generation face. Everyone deserves to die with dignity but Alzheimers is one of those diseases that prevents that. Come on "NICE", be nice for a change!

Chippy75, Chester,

My grandfather,in his last days,always underwent the pains of Alzheimers,he lost his memory.With the dramatically increasing number of eldly people in my country ,lots of aged people will suffer from Alzheimers.I think that the Alzheimers will become a big case which may puzzle our goverment.

david, chengdu,sichuan, china

Any side effects.

shay, houston, tx, usa

Don't for one minute think that NICE will approve this drug for us peasants. It costs as much as Aricept, which they won't allow us to have. The government would rather have us sent home from hospital for families to care for us, with absolutely no support from the State or the NHS.

Paul, Milton Keynes, UK

How does an American citizen with early Alzheimers get on
the clinical trial for phase three of rember? I would like
to volunteer, even if I have to go to Scotland to get it.

helen dunkle, Lady Lake, Florida, USA