Mark Henderson
Attend an evening with Andre Agassi
Autism is a highly heritable disorder, which is strongly influenced by genes. But it is not a genetic condition in the same way as Huntington's disease or cystic fibrosis, in which mutated DNA is the one and only cause. It is influenced by environmental factors, but what they are we do not yet know.
This uncertainty about environmental triggers has itself become a trigger for wild speculation. All sorts of hypothetical causes have been advanced and found wanting, from cold-hearted “refrigerator mothers” to vaccines.
This week a new contender has emerged. In a paper published in Archives of Paediatrics & Adolescent Medicine, Michael Waldman, of Cornell University, has suggested a link to rainfall. He noted that autism prevalence seemed to be lower in the south and west of the United States than in northern states, and wondered whether climate might be responsible. When he studied counties in Oregon, California and Washington, a trend emerged. Autism was more likely to be diagnosed in children living in wetter counties.
This supposed link has been seized on by those who claim, against the evidence, that mercury poisoning causes autism. Rain, they suggest, might be the conduit by which mercury pollution from industry is reaching the ground environment.
That, to be fair, is not Waldman's interpretation. He thinks it more likely that wet weather means children spend more time indoors, which may have knock-on effects. They may watch more TV. They get less sunlight and thus produce less vitamin D. They may be more exposed to household chemicals.
These suggestions are just about plausible - though it beats me how TV might affect a disorder for which warning signs often appear in the first year of life. But before British parents start to worry about our famously soggy climate, it is worth remembering that these are speculative ideas, with little or no evidence to recommend them. The link they purport to explain is in itself rather questionable.
An analysis of the paper by the Respectful Insolence blog (www.scienceblogs.com/ insolence) makes this plain. First, Waldman did not actually find a link between raw precipitation data and autism - rainfall figures had to be adjusted for a trend to emerge. This doesn't necessarily invalidate the claim, but it advises caution. Try enough adjustments, and associations will sometimes emerge through chance alone.
Rainfall, too, is variable from year to year, but the trend of rising autism diagnoses goes in one direction. Prevalence is also similar in many countries with different climates. These inconvenient truths compromise the credibility of the link, yet they pass unexplained. There is every chance that this link is a statistical artifact - and one found in a single region. There is no reason to think it can be generalised beyond the US West Coast.
These criticisms highlight a simple reason why one must always approach statistical studies with great care: correlation is not the same thing as causation. Causation can sometimes be inferred from association, but exacting conditions must be met.
An effect must be seen in multiple independent samples, and there should ideally be a relationship between dose and response. It should also be explicable by biological means, preferably by a mechanism backed by animal or human laboratory research.
In this case, none of these criteria has been fulfilled, casting doubt on whether the paper deserved to be published and reported. As Respectful Insolence says, studies like this are “custom-made for cranks”, as they are impossible to interpret and easily misrepresented to support maverick claims. Rarely do they turn out to be preliminary expositions of important links that have not yet been appreciated. Far more often they are diversions that alarm the public needlessly.
Mark Henderson is science editor of The Times
Industry sectors news at a glance. Interactive heatmap, video and podcast
Everything the Business Traveller needs to know to make a better trip
Get ready for the winter sports season, with our resort guides and snow reports
We are backing British business, what is the confidence of the nation and what businesses are succeeding?
Growing demand for energy, oil that is harder to reach and the rise of carbon dioxide emissions. We examine the energy challenge
With rail travel in Europe on the rise, we review the benefits of travelling by train
Enjoy further reading from Travel to Fashion, Business to Sport, discover more




Shortcuts to help you find sections and articles
1998
£47,955
12 months for the price of 11 and a 5% discount.
Offer ends 31/11/09
Check your free Experian credit report before applying
Car Insurance
to £60K + bonus (OTE £90k)
Lord Search & Selection
Location Flexible
PwC’s Consulting practice helps businesses of all shapes
and sizes work smarter and grow faster.
£85k
CPA
Highly Competitve
Specsavers
Whiteley, near Southampton
Moments from Battersea Park.
For sale with Winkworth
Find out about shared ownership.
See your free Experian credit report beforehand
7nts - Penang £499; Borneo £699; All Inclusive £799 including flights, taxes, accommodation and private transfers
For your ultimate tailor-made ski holiday, click here
Get covered on your travels with a superb range of policies at great prices. Visit InsureandGo.com
World Class Golf, Spa and preferential Beach Club. Private estate overlooking West Coast
Villas from £275 per night inclusive of Golf
Contact our advertising team for advertising and sponsorship in Times Online, The Times and The Sunday Times, or place your advertisement.
Times Online Services: Dating | Jobs | Property Search | Used Cars | Holidays | Births, Marriages, Deaths | Subscriptions | E-paper
News International associated websites: Globrix Property Search | Milkround
Copyright 2009 Times Newspapers Ltd.
This service is provided on Times Newspapers' standard Terms and Conditions. Please read our Privacy Policy.To inquire about a licence to reproduce material from Times Online, The Times or The Sunday Times, click here.This website is published by a member of the News International Group. News International Limited, 1 Virginia St, London E98 1XY, is the holding company for the News International group and is registered in England No 81701. VAT number GB 243 8054 69.