Mark Henderson, Science Editor
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People with asthma and hay fever are being deliberately infected with hookworms to test whether the blood-sucking parasites can control the allergic reactions that cause the conditions.
If the study by British scientists is successful, it would open a new approach to controlling allergic and auto-immune conditions. Hookworm infestations could be induced under medical supervision to reduce symptoms, or the worms could help the development of new drugs. It has been understood since the 1970s that people with hookworms, an intestinal parasite, rarely have allergic conditions such as asthma and hay fever.
There is also evidence that they are protected against multiple sclerosis and Crohn’s disease. Both are caused by the body’s immune system, which overreacts to cause excessive inflammation or to attack healthy tissue.
Parasites such as hookworms can survive only by avoiding detection and destruction by the immune system, and so produce proteins to damp it down. Infections of about ten worms can be tolerated by otherwise healthy people.
Professor David Pritchard of the University of Nottingham, who is leading the research, told the festival yesterday that groups of hayfever sufferers had been given hookworms: “Many of the people who were given a placebo have now requested worms. And the people with worms, many of them have decided to keep them for the next hay fever season.”
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After living with asthma and allergies for 40 years I am ready to consider an alternative, even hookworms. It would be a change, even if only for a year or two to not have to worry about what I eat, what environment I am in and for my body to normalize itself. If I wasn't bothered by the little rascals I might make it a life long experiment.
greg, toronto, Canada
This information would be so good if there was actually somewhere you could get ten or so of these hookworms inside you, but can't find them. Anyone know where i can find these hookworms short of travelling to the cameroon or paying five thousand US dollars?
James, London, England
If by ingesting hookworms helps our immune system to tolerate allergies, and avoid asthma attacks I am all for it.
Would like to know what other consequences could develop, if any, having hookworms in your body.
Silvia, Miami, Florida
silvia fernandez, Miami, Florida
"eeww gross" says the person with a billion different bacterial, fungal and viral organisms living in their body. If you don't suffer from one of the issues (or have yet experienced a life changing debilating disease) then you cannot understand the desperation some experience. People with cancer get chemo which by all reason is crazy and comes with nasty side effects. Hookworms are mild compared to some western treatments. Every man made drug has side effects, many with dangerous or unpleasant effects.
Hookworms do not multiply in your body. Hookworms can be killed in 48 hours with a common drug. Hookworms need to enter through the skin, and this process may be required for them to do what they do.
Western medicine is about profits. If you have allergies, good luck finding a doc that does RUSH or SLIT, two therapies that are faster, cheaper and easier to help allergies - yet few doctors do them because they do not make them as much money.
kal, dallas,
Yes. It is preferable to ingest or inject sometimes toxic chemicals that meerly mask or eliminate symptoms for the rest of your life. I want cures to diseases, not symptoms. I say what ever it takes you need to be open minded enough to look at all options, not just the narrow protocol they learned in medical school.
Michael, Royal Oak, MI
I'd rather wheeze and sneeze.
Joseph Mansfield, Chattanooga, Tennessee
Could they not just try to replicate the protiens created by hookworms as appose to infacting people with parasites?
C Sliney, Essex,
If you had Crohn's Disease you might sing another tune! It's a hideous affliction.
Dan Hermann, Brooklyn, NY USA
Natural parasites I believe can be useful. For example, about a dozen years ago I remember a controversy about a successful diet doctor in Evansville, Indiana. This fellow had an excellent track record in helping extremely obese people lose weight, and this was before the stomach-stapling fad that is the rage nowadays. Come to find out, he was giving these patients a tapeworm cyst via a sugar pill!. No one was the wiser until some patient was discovered to possess a 100 foot long tapeworm in their GI tract. Anyhow, everyone knows the risks of these new weight reducing surgeries, as the recepients of such radical treatments have a significant risk of life threatening complications. However, the tapeworm normally doesn't kill its host. That's something to think about.
William Zeller, Ashland , Kentucky
People are not 'with' asthma and hayfever or any other disease or condition: they 'have' asthma, etc or 'suffer from' the conditions. People are not 'diagnosed with' conditions - it is the conditions that are diagnosed.
R H Reilly, Erith,
Urggggghhhhhhh - Yuk!!!!!!!!!!!!!!!!!!!!
If Scientists think that they're going to infect me with Hook worms, then they're going to be very sadly mistaken!!!! -
Geoff Chaplin, Brighton, UK