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ALLERGIES could soon be treated using new drugs that trick the immune system
into thinking that it is under attack, according to scientists. Allergic
reactions occur when the body’s defences react to harmless substances, such
as pollen, and research suggests that diverting the immune system could be a
successful way of preventing them.
Cytos Biotechnology, a company based in Zurich, Switzerland, has developed an
experimental drug that fools the immune system into thinking that it is
under attack from a germ called mycobacteria, found in dirt, and early
results suggest a benefit for hay fever.
When 10 people suffering from hay fever were injected with the drug, CYT
003-QbG10, their sensitivity to grass pollen was reduced by a factor of 100, New
Scientist magazine reports.
Cytos said that the patients remained symptom-free for up to eight months, but
it is not yet known whether the results are permanent. A previous study
indicated similar benefits for patients allergic to dust mites. They are
symptom-free a year on. Cytos has begun a study on more than 100 people with
hay fever, dust mite allergy and atopic dematitis.
Mycobacteria, also found in soil, are pathogens to which people are exposed at
much lower levels than in the past. Artificial exposure may “reboot” the
immune system.
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